Every August, four women would gather together to spend a week at the beach, renting a new house each year. The ritual began when they were in their twenties and their husbands were in medical school. They called themselves the Girls of August. But when one of the Girls dies tragically, the group slowly drifts apart and their vacations together are brought to a halt. Years later, a new marriage reunites them and they decide to come together once again on a remote barrier island off the South Carolina coast. There, far from civilization, the women make startling discoveries that will change them in ways they never expected.